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Structural and Functional Determinants of γ-Secretase, an Intramembrane Protease Implicated in Alzheimer’s Disease
Alzheimer’s disease is the most common form of neurodegenerative diseases in humans, characterized by the progressive accumulation and aggregation of amyloid-β peptides (Aβ) in brain regions subserving memory and cognition. These 39-43 amino acids long peptides are generated by the sequential proteo...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Bentham Science Publishers Ltd.
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2647162/ https://ncbi.nlm.nih.gov/pubmed/19415127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/138920207783769521 |
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