T CELLS POTENTIATE PTH INDUCED CORTICAL BONE LOSS THROUGH CD40L SIGNALING

PTH promotes bone catabolism by targeting bone marrow stromal cells (SCs) and their osteoblastic progeny. Here we show that a continuous infusion of PTH that mimics hyperparathyroidism fails to induce osteoclast formation, bone resorption and cortical bone loss in mice lacking T cells. T cells provi...

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Detalhes bibliográficos
Main Authors: Gao, Yuhao, Wu, Xiaojun, Terauchi, Masakazu, Li, Jau-Yi, Grassi, Francesco, Galley, Sarah, Yang, Xiaoying, Weitzmann, M. Neale, Pacifici, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569843/
https://ncbi.nlm.nih.gov/pubmed/18680714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.07.001
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