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IFN-γ stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation
T cell–produced cytokines play a pivotal role in the bone loss caused by inflammation, infection, and estrogen deficiency. IFN-γ is a major product of activated T helper cells that can function as a pro- or antiresorptive cytokine, but the reason why IFN-γ has variable effects in bone is unknown. He...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1697800/ https://ncbi.nlm.nih.gov/pubmed/17173138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30074 |
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