IFN-γ stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation

T cell–produced cytokines play a pivotal role in the bone loss caused by inflammation, infection, and estrogen deficiency. IFN-γ is a major product of activated T helper cells that can function as a pro- or antiresorptive cytokine, but the reason why IFN-γ has variable effects in bone is unknown. He...

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Bibliografiska uppgifter
Huvudupphovsmän: Gao, Yuhao, Grassi, Francesco, Ryan, Michaela Robbie, Terauchi, Masakazu, Page, Karen, Yang, Xiaoying, Weitzmann, M. Neale, Pacifici, Roberto
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2006
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697800/
https://ncbi.nlm.nih.gov/pubmed/17173138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30074
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