K-Ras(G12D)–induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors

To study the impact of oncogenic K-Ras on T-cell leukemia/lymphoma development and progression, we made use of a conditional K-Ras(G12D) murine knockin model, in which oncogenic K-Ras is expressed from its endogenous promoter. Transplantation of whole bone marrow cells that express oncogenic K-Ras i...

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Detalhes bibliográficos
Main Authors: Kindler, Thomas, Cornejo, Melanie G., Scholl, Claudia, Liu, Jianing, Leeman, Dena S., Haydu, J. Erika, Fröhling, Stefan, Lee, Benjamin H., Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569181/
https://ncbi.nlm.nih.gov/pubmed/18663146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-147587
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