Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase

Anaplerosis, the synthesis of citric acid cycle intermediates, by pancreatic beta cell mitochondria has been proposed to be as important for insulin secretion as mitochondrial energy production. However, studies designed to lower the rate of anaplerosis in the beta cell have been inconclusive. To te...

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Autores principales: Hasan, Noaman M., Longacre, Melissa J., Stoker, Scott W., Boonsaen, Thirajit, Jitrapakdee, Sarawut, Kendrick, Mindy A., Wallace, John C., MacDonald, Michael J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Metabolism and Bioenergetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568907/
https://ncbi.nlm.nih.gov/pubmed/18697738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804170200
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