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Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase

Anaplerosis, the synthesis of citric acid cycle intermediates, by pancreatic beta cell mitochondria has been proposed to be as important for insulin secretion as mitochondrial energy production. However, studies designed to lower the rate of anaplerosis in the beta cell have been inconclusive. To te...

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Bibliografski detalji
Glavni autori: Hasan, Noaman M., Longacre, Melissa J., Stoker, Scott W., Boonsaen, Thirajit, Jitrapakdee, Sarawut, Kendrick, Mindy A., Wallace, John C., MacDonald, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568907/
https://ncbi.nlm.nih.gov/pubmed/18697738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804170200
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