Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37

Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13, but little is known about the regulation of this essential posttranslational modification. We show that Ser13 of uncomplexed Cdc37 is phosphorylated in vivo...

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Auteurs principaux: Vaughan, Cara K., Mollapour, Mehdi, Smith, Jennifer R., Truman, Andrew, Hu, Bin, Good, Valerie M., Panaretou, Barry, Neckers, Len, Clarke, Paul A., Workman, Paul, Piper, Peter W., Prodromou, Chrisostomos, Pearl, Laurence H.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568865/
https://ncbi.nlm.nih.gov/pubmed/18922470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.021
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