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External Ba(2+) Block of Human Kv1.5 at Neutral and Acidic pH: Evidence for H(o)(+)-Induced Constriction of the Outer Pore Mouth at Rest
Previous studies have shown that low pH(o) accelerates depolarization-induced inactivation and decreases the macroscopic conductance by reducing channel availability. To test the hypothesis that outer pore constriction underlies the decreased conductance at low pH(o), external Ba(2+) was used to exa...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567935/ https://ncbi.nlm.nih.gov/pubmed/18658206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.133165 |
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