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Single Channel Analysis Reveals Different Modes of Kv1.5 Gating Behavior Regulated by Changes of External pH

In the voltage-gated potassium channel Kv1.5, extracellular acidification decreases the peak macroscopic conductance and accelerates slow inactivation. To better understand the mechanistic basis for these two effects, we recorded unitary currents of Kv1.5 expressed in a mouse cell line (ltk(−)) usin...

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Detalhes bibliográficos
Main Authors: Kwan, Daniel C. H., Fedida, David, Kehl, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367272/
https://ncbi.nlm.nih.gov/pubmed/16326898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.068577
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