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Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+)

Using human Kv1.5 channels expressed in HEK293 cells we assessed the ability of [Formula: see text] to mimic the previously reported action of Zn(2+) to inhibit macroscopic hKv1.5 currents, and using site-directed mutagenesis, we addressed the mechanistic basis for the inhibitory effects of [Formula...

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Main Authors: Kehl, Steven J, Eduljee, Cyrus, Kwan, Daniel C H, Zhang, Shetuan, Fedida, David
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290311/
https://ncbi.nlm.nih.gov/pubmed/12015417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.014456
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