Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antibodies. They are immunocompetent and show enhanc...

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Autori principali: Croker, Ben A., Lawson, Brian R., Berger, Michael, Eidenschenk, Celine, Blasius, Amanda L., Moresco, Eva Marie Y., Sovath, Sosathya, Cengia, Louise, Shultz, Leonard D., Theofilopoulos, Argyrios N., Pettersson, Sven, Beutler, Bruce Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567487/
https://ncbi.nlm.nih.gov/pubmed/18806225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806619105
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