Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antibodies. They are immunocompetent and show enhanc...

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Hauptverfasser: Croker, Ben A., Lawson, Brian R., Berger, Michael, Eidenschenk, Celine, Blasius, Amanda L., Moresco, Eva Marie Y., Sovath, Sosathya, Cengia, Louise, Shultz, Leonard D., Theofilopoulos, Argyrios N., Pettersson, Sven, Beutler, Bruce Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567487/
https://ncbi.nlm.nih.gov/pubmed/18806225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806619105
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