Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antibodies. They are immunocompetent and show enhanc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Croker, Ben A., Lawson, Brian R., Berger, Michael, Eidenschenk, Celine, Blasius, Amanda L., Moresco, Eva Marie Y., Sovath, Sosathya, Cengia, Louise, Shultz, Leonard D., Theofilopoulos, Argyrios N., Pettersson, Sven, Beutler, Bruce Alan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567487/
https://ncbi.nlm.nih.gov/pubmed/18806225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806619105
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