Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antibodies. They are immunocompetent and show enhanc...

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Detalhes bibliográficos
Main Authors: Croker, Ben A., Lawson, Brian R., Berger, Michael, Eidenschenk, Celine, Blasius, Amanda L., Moresco, Eva Marie Y., Sovath, Sosathya, Cengia, Louise, Shultz, Leonard D., Theofilopoulos, Argyrios N., Pettersson, Sven, Beutler, Bruce Alan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567487/
https://ncbi.nlm.nih.gov/pubmed/18806225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806619105
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