Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis

Intratumoral innate immunity can play a significant role in blocking the effective therapeutic spread of a number of oncolytic viruses (OVs). Histone deacetylase inhibitors (HDIs) are known to influence epigenetic modifications of chromatin and can blunt the cellular antiviral response. We reasoned...

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Detalhes bibliográficos
Principais autores: Nguyên, Thi Lien-Anh, Abdelbary, Hesham, Arguello, Meztli, Breitbach, Caroline, Leveille, Simon, Diallo, Jean-Simon, Yasmeen, Amber, Bismar, Tarek A., Kirn, David, Falls, Theresa, Snoulten, Valerie E., Vanderhyden, Barbara C., Werier, Joel, Atkins, Harold, Vähä-Koskela, Markus J. V., Stojdl, David F., Bell, John C., Hiscott, John
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567479/
https://ncbi.nlm.nih.gov/pubmed/18815361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803988105
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