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Role of the N-Terminal Domain of φC31 Integrase in attB-attP Synapsis

φC31 integrase is a serine recombinase containing an N-terminal domain (NTD) that provides catalytic activity and a large C-terminal domain that controls which pair of DNA substrates is able to synapse. We show here that substitutions in amino acid V129 in the NTD can lead to defects in synapsis and...

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Détails bibliographiques
Auteurs principaux: Rowley, Paul A., Smith, Margaret C. M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566186/
https://ncbi.nlm.nih.gov/pubmed/18689475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00612-08
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