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Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors

To address the need for broad-spectrum antiviral activity characterization of hepatitis C virus (HCV) polymerase inhibitors, we created a panel of intergenotypic chimeric replicons containing nonstructural (NS) protein NS5B sequences from genotype 2b (GT2b), GT3a, GT4a, GT5a, and GT6a HCV isolates....

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Bibliografski detalji
Glavni autori: Herlihy, Koleen J., Graham, Joanne P., Kumpf, Robert, Patick, Amy K., Duggal, Rohit, Shi, Stephanie T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565898/
https://ncbi.nlm.nih.gov/pubmed/18694956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00533-08
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