In Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

A novel class of nonnucleoside hepatitis C virus (HCV) polymerase inhibitors characterized by a dihydropyrone core was identified by high-throughput screening. Crystallographic studies of these compounds in complex with the polymerase identified an allosteric binding site close to the junction of th...

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Detalhes bibliográficos
Main Authors: Shi, Stephanie T., Herlihy, Koleen J., Graham, Joanne P., Fuhrman, Shella A., Doan, Chau, Parge, Hans, Hickey, Michael, Gao, Jingjin, Yu, Xiu, Chau, Fannie, Gonzalez, Javier, Li, Hui, Lewis, Cristina, Patick, Amy K., Duggal, Rohit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224781/
https://ncbi.nlm.nih.gov/pubmed/18070954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00834-07
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