Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

The virus-encoded nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is an RNA-dependent RNA polymerase and is absolutely required for replication of the virus. NS5B exhibits significant differences from cellular polymerases and therefore has become an attractive target for anti-HCV therapy....

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Detaylı Bibliyografya
Asıl Yazarlar: Love, Robert A., Parge, Hans E., Yu, Xiu, Hickey, Michael J., Diehl, Wade, Gao, Jingjin, Wriggers, Hilary, Ekker, Anne, Wang, Liann, Thomson, James A., Dragovich, Peter S., Fuhrman, Shella A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2003
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC164784/
https://ncbi.nlm.nih.gov/pubmed/12805457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7575-7581.2003
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