Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

The virus-encoded nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is an RNA-dependent RNA polymerase and is absolutely required for replication of the virus. NS5B exhibits significant differences from cellular polymerases and therefore has become an attractive target for anti-HCV therapy....

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Detalhes bibliográficos
Main Authors: Love, Robert A., Parge, Hans E., Yu, Xiu, Hickey, Michael J., Diehl, Wade, Gao, Jingjin, Wriggers, Hilary, Ekker, Anne, Wang, Liann, Thomson, James A., Dragovich, Peter S., Fuhrman, Shella A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164784/
https://ncbi.nlm.nih.gov/pubmed/12805457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7575-7581.2003
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