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De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease

[Image: see text] The Zika virus presents a major public health concern due to severe fetal neurological disorders associated with infections in pregnant women. In addition to vaccine development, the discovery of selective antiviral drugs is essential to combat future epidemic Zika virus outbreaks....

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Nitsche, Christoph, Passioura, Toby, Varava, Paul, Mahawaththa, Mithun C., Leuthold, Mila M., Klein, Christian D., Suga, Hiroaki, Otting, Gottfried
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378662/
https://ncbi.nlm.nih.gov/pubmed/30783498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00535
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