Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

PF-00868554 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, which exerts its inhibitory effect by binding to the thumb base domain of the protein. It is a potent and selective inhibitor, with a mean 50% inhibitory concentration of 0.019 μM against genotype 1 polymerases a...

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Detalhes bibliográficos
Main Authors: Shi, Stephanie T., Herlihy, Koleen J., Graham, Joanne P., Nonomiya, Jim, Rahavendran, Sadayappan V., Skor, Heather, Irvine, Rebecca, Binford, Susan, Tatlock, John, Li, Hui, Gonzalez, Javier, Linton, Angelica, Patick, Amy K., Lewis, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687230/
https://ncbi.nlm.nih.gov/pubmed/19307358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01599-08
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