Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV). We demonstrated earlier that the K291R mutation in the F1 motif of...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Abdelnabi, Rana, de Morais, Ana Theresa Silveira, Leyssen, Pieter, Imbert, Isabelle, Beaucourt, Stéphanie, Blanc, Hervé, Froeyen, Mathy, Vignuzzi, Marco, Canard, Bruno, Neyts, Johan, Delang, Leen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446660/
https://ncbi.nlm.nih.gov/pubmed/28381577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00487-17
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