Mutation Rates of TGFBR2 and ACVR2 Coding Microsatellites in Human Cells with Defective DNA Mismatch Repair

Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFβ family receptors is abrogated in DNA Mismatch repair (MMR)-deficient tumors....

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Bibliografiska uppgifter
Huvudupphovsmän: Chung, Heekyung, Young, Dennis J., Lopez, Claudia G., Le, Thuy-Anh T., Lee, Jeffrey K., Ream-Robinson, Deena, Huang, Sherry C., Carethers, John M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565065/
https://ncbi.nlm.nih.gov/pubmed/18941508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003463
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