Mutation Rates of TGFBR2 and ACVR2 Coding Microsatellites in Human Cells with Defective DNA Mismatch Repair

Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFβ family receptors is abrogated in DNA Mismatch repair (MMR)-deficient tumors....

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Detalhes bibliográficos
Main Authors: Chung, Heekyung, Young, Dennis J., Lopez, Claudia G., Le, Thuy-Anh T., Lee, Jeffrey K., Ream-Robinson, Deena, Huang, Sherry C., Carethers, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565065/
https://ncbi.nlm.nih.gov/pubmed/18941508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003463
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