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Flanking Sequence Specificity Determines Coding Microsatellite Heteroduplex and Mutation Rates with Defective DNA Mismatch Repair (MMR)
The activin type II receptor (ACVR2) contains 2 identical microsatellites in exon 3 and 10, but only the exon 10 microsatellite is frameshifted in MMR-defective colonic tumors. The reason for this selectivity is not known. We hypothesized that ACVR2 frameshifts were influenced by DNA sequences surro...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028169/ https://ncbi.nlm.nih.gov/pubmed/20140012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.508 |
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