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Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C

A group of DAG-lactones with altered functionality (C=O → CH(2) or C=O → C=S) at the sn-1 and sn-2 carbonyl pharmacophores was synthesized and used as probes to dissect the individual role of each carbonyl in binding to protein kinase C (PKC). The results suggest that the hydrated sn-1 carbonyl is e...

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書誌詳細
主要な著者: Kang, Ji-Hye, Peach, Megan L., Pu, Yongmei, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563800/
https://ncbi.nlm.nih.gov/pubmed/16134942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050352m
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