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The splicing-factor oncoprotein SF2/ASF activates mTORC1
The splicing factor SF2/ASF is an oncoprotein that is up-regulated in many cancers and can transform immortal rodent fibroblasts when slightly overexpressed. The mTOR signaling pathway is activated in many cancers, and pharmacological blockers of this pathway are in clinical trials as anticancer dru...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2563124/ https://ncbi.nlm.nih.gov/pubmed/18832178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801376105 |
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