S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1

Ribosomal S6 Kinase 1 (S6K1) is a major mTOR downstream signaling molecule which regulates cell size and translation efficiency. Here we report that short isoforms of S6K1 are over-produced in breast cancer cell lines and tumors. Overexpression of S6K1 short isoforms induces transformation of human...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Ben-Hur, Vered, Denichenko, Polina, Siegfried, Zahava, Maimon, Avi, Krainer, Adrian, Davidson, Ben, Karni, Rotem
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021319/
https://ncbi.nlm.nih.gov/pubmed/23273915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.11.020
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