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Rab1A Is an mTORC1 Activator and a Colorectal Oncogene
Amino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA stimulates Rab1A GTP-binding and interaction with mTORC1, and Rheb-mTORC1 interaction in the Golgi. Rab1A overexpression promote...
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| Izdano u: | Cancer Cell |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4288827/ https://ncbi.nlm.nih.gov/pubmed/25446900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.09.008 |
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