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S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1
Ribosomal S6 Kinase 1 (S6K1) is a major mTOR downstream signaling molecule which regulates cell size and translation efficiency. Here we report that short isoforms of S6K1 are over-produced in breast cancer cell lines and tumors. Overexpression of S6K1 short isoforms induces transformation of human...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5021319/ https://ncbi.nlm.nih.gov/pubmed/23273915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.11.020 |
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