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Short Stereoselective Synthesis of α-Substituted γ-Lactams

A concise, stereoselective synthesis of α-substituted γ-lactams is reported. γ-Lactam scaffolds 2 and 3 possessing an Evans' chiral auxiliary and two types of N-substituents were successfully alkylated with different electrophiles to give α-substituted γ-lactams with reasonable diastereoselecti...

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Bibliografski detalji
Glavni autori: Raghavan, Bhooma, Johnson, Rodney L.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562328/
https://ncbi.nlm.nih.gov/pubmed/16497007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo052212q
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