A Highly Stereoselective Synthesis of Chiral α-Amino-β-Lactams Via the Kinugasa Reaction Employing Ynamides

A highly stereoselective synthesis of chiral α-amino-β-lactam through an ynamide-Kinugasa reaction is described. In addition, a mechanistic model is illustrated here to rationalize the observed diastereoselectivity, which depends on both the initial [3 + 2] cycloaddition step and the subsequent prot...

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Hlavní autoři: Zhang, Xuejun, Hsung, Richard P., Li, Hongyan, Zhang, Yu, Johnson, Whitney L., Figueroa, Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587087/
https://ncbi.nlm.nih.gov/pubmed/18613692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol801257j
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