Disulfide Cross-links Reveal Conserved Features of DNA Topoisomerase I Architecture and a Role for the N Terminus in Clamp Closure

In eukaryotes, DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a conserved mechanism of transient DNA strand breakage, rotation, and religation. The unusual architecture of the monomeric human enzyme comprises a conserved protein clamp, which is tightly wrapped about duplex...

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Bibliographic Details
Main Authors: Palle, Komaraiah, Pattarello, Luca, van der Merwe, Marié, Losasso, Carmen, Benedetti, Piero, Bjornsti, Mary-Ann
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562070/
https://ncbi.nlm.nih.gov/pubmed/18693244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804826200
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