Učitavanje...
Mutation of Gly(721) Alters DNA Topoisomerase I Active Site Architecture and Sensitivity to Camptothecin
DNA topoisomerase I (Top1p) catalyzes the relaxation of supercoiled DNA via a concerted mechanism of DNA strand cleavage and religation. Top1p is the cellular target of the anticancer drug camptothecin (CPT), which reversibly stabilizes a covalent enzyme-DNA intermediate. Top1p clamps around duplex...
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| Izdano u: | J Biol Chem |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4995888/ https://ncbi.nlm.nih.gov/pubmed/18056711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705781200 |
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