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DNA Topoisomerase I Domain Interactions Impact Enzyme Activity and Sensitivity to Camptothecin
During processes such as DNA replication and transcription, DNA topoisomerase I (Top1) catalyzes the relaxation of DNA supercoils. The nuclear enzyme is also the cellular target of camptothecin (CPT) chemotherapeutics. Top1 contains four domains: the highly conserved core and C-terminal domains invo...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424343/ https://ncbi.nlm.nih.gov/pubmed/25795777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.635078 |
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