Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity, and cross-protection against heterologous challenge

Vaccination with Plasmodium sporozoites attenuated by irradiation or genetic manipulation induces a protective immune response in rodent malaria models. Recently, vaccination with chemically attenuated P. berghei sporozoites (CAS) has also been shown to elicit sterile immunity in mice. Here we show...

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Bibliographic Details
Main Authors: Purcell, Lisa A., Wong, Kurt A., Yanow, Stephanie K., Lee, Moses, Spithill, Terry W., Rodriguez, Ana
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2560175/
https://ncbi.nlm.nih.gov/pubmed/18672017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.07.017
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