Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model

With the increasing prevalence of artemisinin-resistant malaria parasites, a highly efficacious and durable vaccine for malaria is urgently required. We have developed an experimental virus-vectored vaccine platform based on an envelope-modified baculovirus dual-expression system (emBDES). Here, we...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yoshida, Kunitaka, Iyori, Mitsuhiro, Blagborough, Andrew M., Salman, Ahmed M., Dulal, Pawan, Sala, Katarzyna A., Yamamoto, Daisuke S., Khan, Shahid M., Janse, Chris J., Biswas, Sumi, Yoshii, Tatsuya, Yusuf, Yenni, Tokoro, Masaharu, Hill, Adrian V. S., Yoshida, Shigeto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832798/
https://ncbi.nlm.nih.gov/pubmed/29497047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21369-y
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