TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

The Trp53 gene family member Trp73 encodes two major groups of protein isoforms, TAp73 and ΔNp73, with opposing pro- and anti-apoptotic functions; consequently, their relative ratio regulates cell fate. However, the precise roles of p73 isoforms in cellular events such as tumor initiation, embryonic...

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Hlavní autoři: Tomasini, Richard, Tsuchihara, Katsuya, Wilhelm, Margareta, Fujitani, Masashi, Rufini, Alessandro, Cheung, Carol C., Khan, Fatima, Itie-Youten, Annick, Wakeham, Andrew, Tsao, Ming-sound, Iovanna, Juan L., Squire, Jeremy, Jurisica, Igor, Kaplan, David, Melino, Gerry, Jurisicova, Andrea, Mak, Tak W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2008
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559903/
https://ncbi.nlm.nih.gov/pubmed/18805989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1695308
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