TAp73 depletion accelerates aging through metabolic dysregulation

Aging is associated with impaired scavenging of reactive oxygen species (ROS). Here, we show that TAp73, a p53 family member, protects against aging by regulating mitochondrial activity and preventing ROS accumulation. TAp73-null mice show more pronounced aging with increased oxidative damage and se...

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Dettagli Bibliografici
Autori principali: Rufini, Alessandro, Niklison-Chirou, Maria Victoria, Inoue, Satoshi, Tomasini, Richard, Harris, Isaac S., Marino, Arianna, Federici, Massimo, Dinsdale, David, Knight, Richard A., Melino, Gerry, Mak, Tak Wah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444727/
https://ncbi.nlm.nih.gov/pubmed/22987635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.197640.112
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