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Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display

The hepatitis C virus (HCV) is a positive strand RNA flavivirus that is a major causative agent of serious liver disease, making new treatment modalities an urgent priority. Because HCV translation initiation occurs by a mechanism that is fundamentally distinct from that of host mRNAs, it is an attr...

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Bibliografiske detaljer
Main Authors: Litovchick, Alexander, Szostak, Jack W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556359/
https://ncbi.nlm.nih.gov/pubmed/18824687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805837105
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