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A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.
Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxyl...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7077329/ https://ncbi.nlm.nih.gov/pubmed/31290487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc10192b |
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