A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxyl...

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Foilsithe in:Chem Commun (Camb)
Main Authors: Iqbal, Emil S., Richardson, Stacie L., Abrigo, Nicolas, Dods, Kara K., Osorio Franco, H. Estheban, Gerrish, Heather, Kotapati, Harikiran, Morgan, Iain M., Masterson, Douglas, Hartman, Matthew C.T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077329/
https://ncbi.nlm.nih.gov/pubmed/31290487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc10192b
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