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Direct, Competitive Comparison of Linear, Monocyclic, and Bicyclic Libraries Using mRNA Display

[Image: see text] Peptide macrocyclization is typically associated with the development of higher affinity and more protease stable protein ligands, and, as such, is an important tool in peptide drug discovery. Yet, within the context of a diverse library, does cyclization give inherent advantages o...

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書誌詳細
出版年:ACS Comb Sci
主要な著者: Hacker, David E., Abrigo, Nicolas A., Hoinka, Jan, Richardson, Stacie L., Przytycka, Teresa M., Hartman, Matthew C. T.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2020
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284801/
https://ncbi.nlm.nih.gov/pubmed/32418423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.0c00016
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