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Highly-constrained bicyclic scaffolds for the discovery of protease-stable peptides via mRNA display
Highly-constrained peptides such as the knotted peptide natural products are promising medicinal agents because of their impressive biostability and potent activity. Yet, libraries of highly-constrained peptides are challenging to prepare. Here we present a method which utilizes two robust, orthogon...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5443354/ https://ncbi.nlm.nih.gov/pubmed/28146347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01006 |
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