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Optimization of the Central Heterocycle of α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase

The synthesis and evaluation of a refined series of α-ketoheterocycles based on the oxazole 2 (OL-135) incorporating systematic changes in the central heterocycle bearing a key set of added substituents are described. The nature of the central heterocycle, even within the systematic and minor pertur...

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Bibliografiske detaljer
Main Authors: Garfunkle, Joie, Ezzili, Cyrine, Rayl, Thomas J., Hochstatter, Dustin G., Hwang, Inkyu, Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556205/
https://ncbi.nlm.nih.gov/pubmed/18630870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800136b
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