Biochemical, Crystallographic and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors

Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28. To explore the biochemical and structural bases for the adenosine phosph...

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Main Authors: Krakowiak, Agnieszka, Pace, Helen C., Blackburn, G. Michael, Adams, Martina, Mekhalfia, Abdelaziz, Kaczmarek, Renata, Baraniak, Janina, Stec, Wojciech J., Brenner, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556070/
https://ncbi.nlm.nih.gov/pubmed/14982931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M314271200
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