Histidine Triad Nucleotide-binding Protein 1 (HINT-1) Phosphoramidase Transforms Nucleoside 5′-O-Phosphorothioates to Nucleoside 5′-O-Phosphates

Nucleoside 5′-O-phosphorothioates are formed in vivo as primary products of hydrolysis of oligo(nucleoside phosphorothioate)s (PS-oligos) that are applied as antisense therapeutic molecules. The biodistribution of PS-oligos and their pharmacokinetics have been widely reported, but little is known ab...

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Bibliographic Details
Main Authors: Ozga, Magdalena, Dolot, Rafal, Janicka, Magdalena, Kaczmarek, Renata, Krakowiak, Agnieszka
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003382/
https://ncbi.nlm.nih.gov/pubmed/20940308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162065
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