Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement

BACKGROUND: The human FHIT gene is inactivated early in the development of many human cancers and loss of Fhit in mouse predisposes to cancer while reintroduction of FHIT suppresses tumor formation via induction of apoptosis. Fhit protein, a diadenosine polyphosphate hydrolase, does not require hydr...

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Détails bibliographiques
Auteurs principaux: Varnum, James M, Baraniak, Janina, Kaczmarek, Renata, Stec, Wojciech J, Brenner, Charles
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2001
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC59680/
https://ncbi.nlm.nih.gov/pubmed/11701096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-1-3
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