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γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe consequences for cell survival and the maintenance of genomic stability. In higher eukaryotic cells, DSBs in chromatin promptly initiate the phosphorylation of the histone H2A variant, H2AX, at Serine 139 to generate γ-H2AX....
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553572/ https://ncbi.nlm.nih.gov/pubmed/18772227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn550 |
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