γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe consequences for cell survival and the maintenance of genomic stability. In higher eukaryotic cells, DSBs in chromatin promptly initiate the phosphorylation of the histone H2A variant, H2AX, at Serine 139 to generate γ-H2AX....

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Bibliographische Detailangaben
Hauptverfasser: Kinner, Andrea, Wu, Wenqi, Staudt, Christian, Iliakis, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
Schlagworte:
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553572/
https://ncbi.nlm.nih.gov/pubmed/18772227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn550
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