γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe consequences for cell survival and the maintenance of genomic stability. In higher eukaryotic cells, DSBs in chromatin promptly initiate the phosphorylation of the histone H2A variant, H2AX, at Serine 139 to generate γ-H2AX....

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Hlavní autoři: Kinner, Andrea, Wu, Wenqi, Staudt, Christian, Iliakis, George
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553572/
https://ncbi.nlm.nih.gov/pubmed/18772227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn550
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