Discovery of Aminoquinolines as a New Class of Potent Inhibitors of Heat Shock Protein 90 (Hsp90): Synthesis, Biology and Molecular Modeling

The molecular chaperone Hsp90 plays important roles in maintaining the malignant phenotypes. Recent studies suggest that Hsp90 exerts high affinity interactions with multiple oncoproteins, which are essential for the growth of tumor cells. As a result, research has been focused on finding Hsp90 prob...

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Detalhes bibliográficos
Main Authors: Ganesh, Thota, Min, Jaeki, Thepchatri, Pahk, Du, Yuhong, Li, Lian, Lewis, Iestyn, Wilson, Larry, Fu, Haian, Chiosis, Gabriela, Dingledine, Raymond, Liotta, Dennis, Snyder, James P., Sun, Aiming
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553564/
https://ncbi.nlm.nih.gov/pubmed/18571929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.05.047
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