Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

OBJECTIVE—Insulin resistance in skeletal muscle plays a critical role in the pathogenesis of type 2 diabetes, yet the cellular mechanisms responsible for insulin resistance are poorly understood. In this study, we examine the role of serine phosphorylation of insulin receptor substrate (IRS)-1 in me...

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Bibliografiske detaljer
Main Authors: Morino, Katsutaro, Neschen, Susanne, Bilz, Stefan, Sono, Saki, Tsirigotis, Dimitrios, Reznick, Richard M., Moore, Irene, Nagai, Yoshio, Samuel, Varman, Sebastian, David, White, Morris, Philbrick, William, Shulman, Gerald I.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2008
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551673/
https://ncbi.nlm.nih.gov/pubmed/18633112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-0454
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