Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

To further explore the nature of the mitochondrial dysfunction and insulin resistance that occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents with type 2 diabetes (IR offspring), we measured mitochondrial content by electron microscopy and insulin signaling in...

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Autors principals: Morino, Katsutaro, Petersen, Kitt Falk, Dufour, Sylvie, Befroy, Douglas, Frattini, Jared, Shatzkes, Nadine, Neschen, Susanne, White, Morris F., Bilz, Stefan, Sono, Saki, Pypaert, Marc, Shulman, Gerald I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280967/
https://ncbi.nlm.nih.gov/pubmed/16284649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25151
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